SAVING Study
The SAVING BABIES study - Sonographic Assessment Validation study for Neonatal Global health improvement
Principal Investigator: Gabriel Altit, Neonatologist, Montreal Children’s Hospital
Co-PI: Irina Prelipcean (University of Rochester [UofR])
Collaborators: Pia Wintermark (MCH), Michelle Ryan (MCH), Anie Lapointe (CHUSJ), Elisa Ruano Cea (MCH), Wadi Mawad (MCH), Joseph Kuebler (UofR).
Supported by the Montreal Children's Hospital Foundation - New Direction Grant
April 24, 2024 - We are pleased to announce the recruitment of our first patient for the SAVING Study at the Montreal Children's Hospital site. We extend our gratitude to the family for agreeing to participate in this project, thereby enabling us to refine the procedural workflow for our collaborating sites. Stay tuned for more updates on this project! Here is a picture taken while we were conducting scans for this project.
24 avril 2024 - Nous sommes heureux d'annoncer le recrutement de notre premier patient pour l'étude SAVING au site de l'Hôpital pour enfants de Montréal. Nous tenons à remercier la famille d'avoir accepté de participer à ce projet, ce qui nous permet d'affiner le déroulement de la procédure pour nos sites collaborateurs. Restez à l'écoute pour plus de mises à jour sur ce projet ! Voici une photo prise lors de la réalisation des scans pour ce projet.
Team at University of Rochester
Irina Prelipcean, MD
Neonatologist and Neonatal Hemodynamics Specialist, co-PI SAVING
Dr. Prelipcean is an Assistant Professor of Pediatrics in the Division of Neonatology at University of Rochester who cares for sick newborns in the neonatal ICU. She graduated from the University of Central Florida College of Medicine as part of the school’s charter class. She completed her residency and neonatology fellowship at the University of Florida Health Shands Children's Hospital. Her area of academic focus is the improvement of outcomes in critically ill neonates, specifically on the hemodynamics and biomarkers involved in neonatal adrenal and brain dysfunction. She has a special interest in point-of-care ultrasound and targeted echocardiography in the neonatal ICU. Dr. Prelipcean is the co-investigator and local PI (University of Rochester) to the SAVING study.
Rachel Jones
Sr. Human Subjects Research Coordinator
I am originally from California and relocated to Rochester, New York in 2018 where I joined the NICU research team at the Golisano Children’s Hospital as a Senior Clinical Research Coordinator. My role in the studies we conduct involves coordinating with various departments during the study start-up phase to assist with the contract and budget creation, obtaining initial IRB approval and coordinating the necessary training for the NICU staff and Providers prior to opening enrollment in the study. Once the study begins, I’m responsible for subject screening and enrollment, coordination of study procedures, data collection and providing continued regulatory support and maintenance for the duration of the study.
I have four children of my own who are my entire world! Working on the clinical trials in our NICU is a constant reminder of grateful I am to have healthy children and just how important research is for these babies and their families. I absolutely love being apart of the work being done to improve outcomes for the babies both here at our institution and other centers we collaborate with for these studies.
Joseph D. Kuebler, MD, MBA, FAAP, FACC
Pediatric Critical Care and Cardiology
Dr. Kuebler is a pediatric cardiac intensivist with board certifications in both pediatric critical care and pediatric cardiology. He attended medical school at the Jacobs School of Medicine and Biomedical Sciences in Buffalo, NY. Dr. Kuebler completed his pediatric residency at Yale New Haven Children’s Hospital including a year as a chief resident. He then went on to do a pediatric cardiology fellowship at Boston Children's Hospital/Harvard Medical School including a year of advanced cardiac imaging (TEE, fetal echocardiography and cardiac MRI). Most recently, Dr. Kuebler returned to western NY for a pediatric critical care fellowship at the University of Rochester Medical Center/Golisano Children's Hospital. He is an associate professor of pediatrics in the divisions of pediatric critical care and cardiology and is the medical director of the pediatric cardiac care center.
Dr. Kuebler's clinical focus is in the pediatric cardiac intensive care unit as well as in point-of-care ultrasound, and transthoracic echocardiography. He is the local clinical champion for the Pediatric Cardiac Critical Care Consortium (PC4), a national quality improvement collaborative and is the director of pediatric critical care ultrasound.
Pamphlet for family - Français & English
Protocol
Consent form in French / Consentement en français
Consent form in English
Data dictionnary / codebook
Data collection sheet and procedures
Procedures
Video for procedures
Still-frames for Parasternal Long Axis
LA/Ao M-Mode
Tip of Mitral Valve M-Mode
Aortic valve - peak of opening for LVOT measurement
Posterior - Tricuspid valve opening
Still frame at Pulmonary Valve opening
Clip with anterior sweep for pulmonary valve.
Still-frames for Parasternal Short Axis
Peak of diastole (filled) at papillary muscle view
Peak of systole (contracted) at papillary muscle view
M-Mode at tip of mitral valve
LA/Ao M-Mode
Still frame at Pulmonary Valve opening
Another Still frame at Pulmonary Valve opening
RVOT - PW Doppler with baseline completely to the top.
Still-frames for Apical Views
Apical 4 chamber view.
Apical 2 chamber view.
Peak of diastole for RV (TV opened)
Peak of diastole for RV (TV closed)
Peak of systole for RV (RV closed)
TAPSE - M-Mode crossing Apex and Tricuspid attachement to free wall
A4C with Tricuspid and Mitral valve open in diastole.
Peak of diastole for LV (MV closed)
Peak of systole for LV (MV closed)
Another peak of diastole for LV (MV closed)
Another peak of systole for LV (MV closed)
MAPSE - M-Mode crossing Apex and Mitral attachement to free wall
Peak of diastole for LV (MV open for MV measurement)
A2C
Peak of diastole - A2C
Peak of systole - A2C
A5C with visualization of LVOT
Suprasternal and PDA view
Colour in descending arch
Arch by 2D clip
Still frame of arch at peak of filling.
PDA sweep - no PDA.
Subcostal view
Subcostal view. The Liver is on top of the screen. The right atrium sits on the liver and the left atrium is posterior.
By using colour flow from the cardiac present (pediatric) we can appreciate the presence of a left to right inter-atrial shunt (likely patent foramen ovale)
Head Ultrasound
Coronal view for ventricular size (lateral ventricle with 3rd ventricle view)
Corpus callosum area on sagittal view
Coronal view for ventricular size (lateral ventricle with 3rd ventricle view)